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Polygenic Risk of Epilepsy and Poststroke Epilepsy.

Stroke - 1 Dec 2024

Clocchiatti-Tuozzo Santiago, Rivier Cyprien A, Misra Shubham, Zelano Johan, Mazumder Rajarshi, Sansing Lauren H, de Havenon Adam, Hirsch Lawrence J, Liebeskind David S, Gilmore Emily J, Sheth Kevin N, Kim Jennifer A, Worrall Bradford B, Falcone Guido J, Mishra Nishant K

Abstract excerpt

BACKGROUND: Epilepsy is highly heritable, with numerous known genetic risk loci. However, the genetic predisposition's role in poststroke epilepsy (PSE) remains understudied. This study assesses whether a higher genetic predisposition to epilepsy raises poststroke survivor's risk of PSE. METHODS: We conducted a case-control genetic association study nested within the UK Biobank, a large UK-based prospective...

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Identifiers

PMID: 39502073
DOI: 10.1161/STROKEAHA.124.047459
PMCID: PMC11653790

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