Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.

doi:10.1002/epi.70353

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Article

Variability in epilepsy polygenic risk prediction across Taiwanese population and clinical cohorts.

Epilepsia - 1 Sept 2026

Ke Yi-Syuan, Tsai Meng-Han, Ho Chen-Rui, Chou Che-Yu, Chen Hung-Hsin, Stevelink Remi, Chen Siwei, Chen Paul Chih-Hsueh, Liu Yo-Tsen, Tung Hsin, Hsiao Tzu-Hung, Tseng Sung-Hui, Chan Lung, Lee Tsong-Hai, Cheng Chih-Kuang, Jeng Jiann-Shing, Lin Chin-Hsien, Hsu Chung-Yao, Yang Yuan-Han, Yang Shun-Fa, Fan Ying-Chi, Yang Fu-Chi, Sung Yueh-Feng, Lin Shinn-Zong, Wang Tso-Fu, Liu Yuan-Hung, Chu Yu-Cheng, Chen Ming, Chang Ming-Yuh, Lee Sing-Lian, Chang Che-Cheng, Huang Yung-Chuan, Cheng Wei-Ming, Chen Shiou-Sheng, Su Yu-Hsiang, Sung Sheng-Feng, Lee Mei-Ching, Chen Jen-Tse, Feng Yen-Chen Anne

Abstract excerpt

OBJECTIVE: This study was undertaken to evaluate the predictive, stratification, and prognostic utility of polygenic risk scores (PRSs) for epilepsy in three Taiwanese cohorts comprising more than 7000 cases among more than 600 000 individuals, thereby addressing the limited evidence on PRS performance in non-European populations. METHODS: Leveraging results from the latest multiancestry genome-wide association...

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Topics

Humans
Taiwan
Genetic Risk Score

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Male

Female

Epilepsy

Cohort Studies

Adult

Genetic Predisposition to Disease

Middle Aged

Multifactorial Inheritance

Epilepsy, Generalized

Epilepsies, Partial

Age of Onset

Source

Open in PubMed

Identifiers

PMID: 42347787
DOI: 10.1002/epi.70353

Provenance

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