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Article

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events.

Nature communications - 25 Jul 2024

Heyne Henrike O, Pajuste Fanny-Dhelia, Wanner Julian, Daniel Onwuchekwa Jennifer I, Mägi Reedik, Palotie Aarno, Kälviainen Reetta, Daly Mark J

Abstract excerpt

A diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 700k Finns and Estonians. We found that a high genetic generalized epilepsy PRS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39054313
DOI: 10.1038/s41467-024-50295-z
PMCID: PMC11272783

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