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Article

Polygenic risk heterogeneity among focal epilepsies.

Epilepsia - 1 Nov 2020

Gramm Marie, Leu Costin, Pérez-Palma Eduardo, Ferguson Lisa, Jehi Lara, Daly Mark J, Najm Imad M, Busch Robyn M, Lal Dennis

Abstract excerpt

Focal epilepsy (FE) is clinically highly heterogeneous. It has been shown recently that not only rare but also a subset of common genetic variants confer risk for FE. The relatively modest power of genetic studies in FE suggests a high genetic heterogeneity of FE when grouped as one disorder. We hypothesize that the clinical heterogeneity of FE is correlated with genetic heterogeneity on a common risk variant...

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Identifiers

PMID: 33090489
DOI: 10.1111/epi.16717
PMCID: PMC13178686

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