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Article

Monogenic no more: are all epilepsies polygenic?

Trends in genetics : TIG - 1 May 2026

Piet M Martijn, Braun Kees P J, Koeleman Bobby P C, Stevelink Remi

Abstract excerpt

The etiology of epilepsy has long been framed by dichotomies, classifying epilepsies as genetic or nongenetic, and genetic epilepsies as monogenic or polygenic. Emerging evidence challenges these divisions. Genome-wide association and sequencing studies show that both common and rare variants contribute to risk, with the phenotype of rare high-impact variants being influenced by an individual's polygenic...

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PMID: 41672837
DOI: 10.1016/j.tig.2026.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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