Article
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates.
Angewandte Chemie (International ed. in English) - 27 Jul 2020
Baalmann Mathis, Neises Laura, Bitsch Sebastian, Schneider Hendrik, Deweid Lukas, Werther Philipp, Ilkenhans Nadja, Wolfring Martin, Ziegler Michael J, Wilhelm Jonas, Kolmar Harald, Wombacher Richard
Abstract excerpt
Bioorthogonal chemistry holds great potential to generate difficult-to-access protein-protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts, or often do not result in quantitative product formation. Here we present a highly efficient technology for protein functionalization with commonly used...
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