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In Silico Screening Using Freely Available Computational Tools to Generate Novel Peptide/Protein Pairs for Protein-Protein Ligation.

Chembiochem : a European journal of chemical biology - 15 Jun 2026

Kawai Haruka, Miura Daimei, Kudo Genki, Hirao Takumi, Asano Ryutaro, Tsugawa Wakako, Hirokawa Takatsugu, Ikebukuro Kazunori

Abstract excerpt

Protein-protein ligation technology, such as SpyTag/SpyCatcher (ST/SC), enables the formation of functional protein complexes and has great potential for applications to biosensor development. The development of orthogonal Tag/Catcher pairs should expand the Tag/Catcher toolbox for the construction of intricately controlled complexes. Because some Tag/Catcher pairs show limited reaction rates, mutations to...

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PMID: 42281341
DOI: 10.1002/cbic.70427

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