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New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue

26 Jun 2018

Abstract excerpt

Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-chimeric VLP-based vaccines are highly successful licensed products (e.g., hepatitis B surface antigen VLPs as a hepatitis B virus vaccine). Chimeric VLPs are designed to take advantage of the VLP framework by decorating the VLP with a different antigen. Despite decades of effort, there have been few licensed chimeric VLP...

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PMID: 29997617
DOI: 10.3389/fimmu.2018.01432

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