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Insulin synthesis is sustained by Tent5 poly(A) polymerases

2026-07-06

Abstract excerpt

Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe health complications in humans. It is therefore essential to understand how beta cells control insulin synthesis and secretion, including the transcription, translation and decay of its messenger RNA. Using sequencing-based poly(A) tail length profiling from human tissue,...

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Literature Corpus work
71348f37-486c-54b9-a1ee-a12aadc72a7f
DOI
10.64898/2026.07.04.736497
Open publication

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