Article

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

2020-08-20

Abstract excerpt

Osteoblasts orchestrate bone formation by secreting dense, highly cross-linked type I collagen and other proteins involved in osteogenesis. Mutations in Col1α1, Col1α2, or collagen biogenesis factors lead to the human genetic disease, osteogenesis imperfecta (OI). Herein, we show that the TENT5A gene, whose mutation is responsible for poorly characterized type XVIII OI, encodes an active cytoplasmic poly(A) polyme...

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Literature Corpus work: 06150152-c794-5dd7-ac80-1932c1869ea7
DOI: 10.1101/2020.08.18.256115

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