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Article

Capability of utilizing CYP3A5 polymorphisms to predict therapeutic dosage of tacrolimus at early stage post-renal transplantation.

International journal of molecular sciences - 14 Jan 2015

Niioka Takenori, Kagaya Hideaki, Saito Mitsuru, Inoue Takamitsu, Numakura Kazuyuki, Habuchi Tomonori, Satoh Shigeru, Miura Masatomo

Abstract excerpt

While CYP3A5 polymorphisms are used to predict the initial dosage of tacrolimus therapy, the predictive capability of genetic information for dosing at early stage post-renal transplantation is unknown. We investigated the influence of polymorphisms over time. An initial oral dose of modified-release once-daily tacrolimus formulation (0.20 mg/kg) was administered to 50 Japanese renal transplant patients every 24...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25594874
DOI: 10.3390/ijms16011840
PMCID: PMC4307337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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