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Article

Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice.

Molecular oncology - 1 Aug 2020

Hedegger Kathrin, Algül Hana, Lesina Marina, Blutke Andreas, Schmid Roland M, Schneider Marlon R, Dahlhoff Maik

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers. The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR). Although EGFR is a crucial player in PDAC development, EGFR-based therapy is disappointing. In this study, we evaluated the role of the EGFR ligand betacellulin (BTC) in PDAC. The expression of BTC was investigated in human...

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Topics

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Share to Body Weight
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erb-b2 Receptor Tyrosine Kinases

Share to Pancreas

Share to Pancreatic Neoplasms

Share to ras Proteins

Share to Receptor, ErbB-4

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Source

Open in PubMed Open full text

Identifiers

PMID: 32335999
DOI: 10.1002/1878-0261.12699
PMCID: PMC7400790

Genes

BTC
EGFR
ERBB2
ERBB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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