Article
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.
Genes & development - 15 Nov 2006
Ijichi Hideaki, Chytil Anna, Gorska Agnieszka E, Aakre Mary E, Fujitani Yoshio, Fujitani Shuko, Wright Christopher V E, Moses Harold L
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly lethal disease in humans. Transforming growth factor-beta (TGF-beta) signaling plays an important role in PDAC progression, as indicated by the fact that Smad4, which encodes a central signal mediator downstream from TGF-beta, is deleted or mutated in 55% and the type II TGF-beta receptor (Tgfbr2) gene is altered in a smaller subset of human PDAC....
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