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Article

Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.

Human molecular genetics - 1 Jul 2015

Coetzee Simon G, Shen Howard C, Hazelett Dennis J, Lawrenson Kate, Kuchenbaecker Karoline, Tyrer Jonathan, Rhie Suhn K, Levanon Keren, Karst Alison, Drapkin Ronny, Ramus Susan J, Couch Fergus J, Offit Kenneth, Chenevix-Trench Georgia, Monteiro Alvaro N A, Antoniou Antonis, Freedman Matthew, Coetzee Gerhard A, Pharoah Paul D P, Noushmehr Houtan, Gayther Simon A

Abstract excerpt

Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants. Here, we describe genome-wide annotation of regions of open chromatin and histone modification in fallopian tube...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 25804953
DOI: 10.1093/hmg/ddv101
PMCID: PMC4459387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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