Article
Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis.
Cell metabolism - 5 May 2020
Zhao Jun, Tian Mao, Zhang Shu, Delfarah Alireza, Gao Ruoyun, Rao Youliang, Savas Ali Can, Lu Anjie, Bubb Larissa, Lei Xiao, Moshirian Rosa, Zhu Wenjie, Peng Cheng, Jiang Taijiao, Chen Lin, Graham Nicholas A, Feng Pinghui
Abstract excerpt
Cell proliferation and inflammation are two metabolically demanding biological processes. How these competing processes are selectively executed in the same cell remains unknown. Here, we report that the enzyme carbamoyl-phosphate synthetase, aspartyl transcarbamoylase, and dihydroorotase (CAD) deamidates the RelA subunit of NF-κB in cancer cells to promote aerobic glycolysis and fuel cell proliferation in...
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