Article
Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.
PloS one - 1 Jan 2013
Jiang Xuejuan, Castelao J Esteban, Vandenberg David, Carracedo Angel, Redondo Carmen M, Conti David V, Paredes Cotoré Jesus P, Potter John D, Newcomb Polly A, Passarelli Michael N, Jenkins Mark A, Hopper John L, Gallinger Steven, Le Marchand Loic, Martínez María E, Ahnen Dennis J, Baron John A, Lindor Noralane M, Haile Robert W, Gago-Dominguez Manuela
Abstract excerpt
BACKGROUND: Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry. MATERIALS AND METHODS: 23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal...
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