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Article

A Systematic Analysis of Interactions between Environmental Risk Factors and Genetic Variation in Susceptibility to Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2020

Yang Tian, Li Xue, Farrington Susan M, Dunlop Malcolm G, Campbell Harry, Timofeeva Maria, Theodoratou Evropi

Abstract excerpt

BACKGROUND: The underlying etiology of colorectal cancer includes both genetic variation and environmental exposures. The main aim of this study was to search for interaction effects between well-established environmental risk factors and published common genetic variants exerting main effects on colorectal cancer risk. METHODS: We used a two-phase approach: (i) discovery phase (2,652 incident colorectal cancer...

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Identifiers

PMID: 32238408
DOI: 10.1158/1055-9965.EPI-19-1328
PMCID: PMC7311198

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