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Article

Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer

22 Apr 2020

Abstract excerpt

Abstract Purpose: Although taxane-based therapy is standard treatment for advanced gastric cancer, a majority of patients exhibit intrinsic resistance to taxanes. Here, we aim to identify the molecular basis of taxane resistance in gastric cancer. Experimental Design: We performed a post hoc analysis of the TAX-325 clinical trial and molecular interrogation of gastric cancer cell lines to assess the benefit of...

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PMID: 32321717
DOI: 10.1158/1078-0432.ccr-19-3018

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