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Article

FOXJ1 mediates taxane resistance through regulation of microtubule dynamics

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Docetaxel is the first-line chemotherapy for metastatic castration-resistant prostate cancer (PC), but clinically meaningful mechanisms of resistance remain to be established. We generated an in vivo model of docetaxel resistance using castration-resistant patient-derived xenografts and found increased expression of genes that drive development of multiciliated cells, including FOXJ1 and its e...

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Literature Corpus work
3ec3443a-3c07-5e09-b8ed-016448f92df0
DOI
10.1101/2025.08.20.671322
Open publication

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