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Article

Effects of the mTOR and AKT genes polymorphisms on systemic lupus erythematosus risk.

Molecular biology reports - 1 May 2020

Saravani Mohsen, Shahraki-Ghadimi Hossein, Maruei-Milan Rostam, Mehrabani Mehrnaz, Mirzamohammadi Solmaz, Nematollahi Mohammad Hadi

Abstract excerpt

The systemic lupus erythematosus (SLE) is an autoimmune disease, leading to inflammatory response and systemic consequences. The mammalian target of rapamycin (mTOR) is a therapeutic target for autoimmune diseases like SLE. The aim of this study was to evaluate the effects of the mTOR rs2295080 and rs2536 polymorphisms and AKT1 rs2494732 gene polymorphism on SLE development. 2 ml of peripheral blood was collected...

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Share to Case-Control Studies
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Share to Lupus Erythematosus, Systemic
Share to Polymorphism, Single Nucleotide
Share to Proto-Oncogene Proteins c-akt
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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 32319007
DOI: 10.1007/s11033-020-05446-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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