Article
Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers.
International journal of molecular sciences - 16 Apr 2020
Jessurun Naomi T, Wijnen Petal A, Bast Aalt, van Puijenbroek Eugène P, Bekers Otto, Drent Marjolein
Abstract excerpt
Drugs are serious but underestimated causative agents of interstitial lung disease (ILD). Both cytotoxic and immune mechanisms may be involved in drug-induced ILD (DI-ILD). We aimed to investigate whether polymorphisms of relevant CYP enzymes involved in the metabolization of tamsulosin might explain the pathologic mechanism of the DI-ILD in the cases with suspected tamsulosin DI-ILD. We collected 22...
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