Article
Role of cytochrome P450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands.
Drug safety - 1 Jan 2008
Wijnen Petal A H M, Drent Marjolein, Nelemans Patty J, Kuijpers Petra M J C, Koek Ger H, Neef Cees, Haenen Guido R M M, Bekers Otto
Abstract excerpt
BACKGROUND: Drug-induced pulmonary toxicity is a serious and expanding problem with often unknown aetiology. Many drugs are metabolized by cytochrome P450 (CYP) enzymes. OBJECTIVE: To establish whether allelic variation in CYP polymorphic genes contributes to variability in drug response and unexpected toxicity. METHODS: A case-control study was conducted. The cases consisted of patients with drug-induced...
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