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Article

Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.

Psychiatry research - 1 Jun 2020

Savadlou Aisouda, Arnatkeviciute Aurina, Tiego Jeggan, Hawi Ziarih, Bellgrove Mark A, Fornito Alex, Bousman Chad

Abstract excerpt

Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample...

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Identifiers

PMID: 32315880
DOI: 10.1016/j.psychres.2020.112984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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