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Article

Estrogen and the male hippocampus: genetic variation in the aromatase gene predicting serum estrogen is associated with hippocampal gray matter volume in men.

Hippocampus - 1 Feb 2013

Bayer Janine, Rune Gabriele, Kutsche Kerstin, Schwarze Ulrike, Kalisch Raffael, Büchel Christian, Sommer Tobias

Abstract excerpt

The neurosteroid 17-beta estradiol (E2) plays an important role in neuronal plasticity, neurogenesis and neuroprotection of hippocampal neurons in slice cultures and the female brain. While some effects of E2 on hippocampal neurons observed in females were also seen in the male hippocampus, others seem to be specific to females. The current study aimed to further explore the effect of E2 on the male hippocampus...

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Identifiers

PMID: 22887836
DOI: 10.1002/hipo.22059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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