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Article

Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain.

Translational psychiatry - 8 Sept 2021

Stingl Julia C, Scholl Catharina, Bosch Julia E, Viviani Roberto

Abstract excerpt

Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyond drug metabolism. CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affinity for endogenous compounds including monoaminergic...

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PMID: 34497262
DOI: 10.1038/s41398-021-01591-5
PMCID: PMC8426391

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