Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene

23 Jul 2013

Abstract excerpt

Selective serotonin reuptake inhibitors, tricyclic antidepressants, various psychoactive drugs, as well as endogenous steroids and cannabinoid-like compounds are metabolized by the polymorphic cytochrome P450 2C19 (CYP2C19). Absence of this enzyme has been recently shown to associate with lower levels of depressive symptoms in human subjects. To investigate endogenous functions of CYP2C19 and its potential role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Pharmacogenetics and Drug Metabolism
Share to Stress Responses and Cortisol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23877834
DOI: 10.1038/mp.2013.89

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 genePMID 23877834Read ↗

Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.Semantic proximity Read ↗

Humanized <i>CYP2C19</i> transgenic mouse as an animal model of cerebellar ataxiaSemantic proximity Read ↗

Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain.Semantic proximity Read ↗

Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brainSemantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

The mouse-equivalent of the human BDNF VAL66MET polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure.Semantic proximity Read ↗

Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice.Semantic proximity Read ↗

Polymorphic Expression of Cyp2C19 and Cyp2D6 in the Developing and Adult Human Brain Causing Variability in Cognition, Risk for Depression and Suicide: The Search for the Endogenous SubstratesSemantic proximity Read ↗

Flowers for Algernon: steroid dysgenesis, epigenetics and brain disorders.Semantic proximity Read ↗

Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercurySemantic proximity Read ↗

Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GR(DBHCre) mice.Semantic proximity Read ↗

Region-specific regulation of the serotonin 2A receptor expression in development and ageing in post mortem human brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.