Article

Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain

2020-12-18

Abstract excerpt

Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyond drug metabolism. CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affinity for endogenous compounds including monoaminergic neurotransmitte...

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Literature Corpus work: 4ffe875d-732d-53e0-b209-10a8255265a2
DOI: 10.1101/2020.12.18.423183

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