Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under Hypoxia

1 Sept 2020

Abstract excerpt

A major hurdle in the treatment of cancer is chemoresistance induced under hypoxia that is characteristic of tumor microenvironment. Triptolide, a potent inhibitor of eukaryotic transcription, possesses potent antitumor activity. However, its clinical potential has been limited by toxicity and water solubility. To address those limitations of triptolide, we designed and synthesized glucose-triptolide conjugates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Synthase and ATPases Research
Share to Histone Deacetylase Inhibitors Research
Share to Natural Compounds in Disease Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33083765
DOI: 10.1016/j.isci.2020.101536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Glucose-Triptolide Conjugate Selectively Targets Cancer Cells under HypoxiaPMID 33083765Read ↗

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism.Semantic proximity Read ↗

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistanceSemantic proximity Read ↗

Therapeutic Targeting of Hypoxia-Inducible Factors in CancerSemantic proximity Read ↗

LC-mHTT-AN2 oversees lactate transport, hypoxia, and glucose homeostasis through dual regulation of MCT-1/4 in the tumor microenvironmentSemantic proximity Read ↗

D-Allose Inhibits Cancer Cell Growth by Reducing GLUT1 ExpressionSemantic proximity Read ↗

Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics DevelopmentSemantic proximity Read ↗

Hypoxic Regulation of Glucose Transport, Anaerobic Metabolism and Angiogenesis in Cancer: Novel Pathways and Targets for Anticancer TherapeuticsSemantic proximity Read ↗

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compoundsSemantic proximity Read ↗

Design, synthesis and biological evaluation of novel tumor hypoxia-activated EGFR tyrosine kinase inhibitors.Semantic proximity Read ↗

Targeting the Warburg Effect with the Glucose Mutation Theory: A Case Study of 36-Year-Old Female Treated for Stage IV Metastatic TPBCUsing Glucosodiene Over a 15-Day PeriodSemantic proximity Read ↗

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancerSemantic proximity Read ↗

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.