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Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

20 Feb 2020

Abstract excerpt

Triptolide is a trace natural product of Tripterygium wilfordii. It has antitumor activities, particularly against pancreatic cancer cells. Identification of genes and elucidation of the biosynthetic pathway leading to triptolide are the prerequisite for heterologous bioproduction. Here, we report a reference-grade genome of T. wilfordii with a contig N50 of 4.36 Mb. We show that copy numbers of triptolide...

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PMID: 32080175
DOI: 10.1038/s41467-020-14776-1

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