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Article

Inhibition of TPI1 Sensitizes Cisplatin-Resistant Oral Cancer to Ferroptosis

19 May 2025

Abstract excerpt

Background: Iron metabolism has emerged as a critical factor in cancer biology, with elevated intracellular iron levels contributing to increased oxidative stress and tumorigenesis. However, the molecular determinants governing ferroptosis sensitivity remain incompletely understood. Triosephosphate isomerase 1 (TPI1), a key glycolytic enzyme, has been implicated in cancer progression, but its role in ferroptosis...

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PMID: 40427052
DOI: 10.3390/biomedicines13051225

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