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Article

Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington disease.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Cayzac Sebastien, Delcasso Sebastien, Paz Vietminh, Jeantet Yannick, Cho Yoon H

Abstract excerpt

In hereditary neurodegenerative Huntington disease (HD), early cognitive impairments before motor deficits have been hypothesized to result from dysfunction in the striatum and cortex before degeneration. To test this hypothesis, we examined the firing properties of single cells and local field activity in the striatum and cortex of pre-motor-symptomatic R6/1 transgenic mice while they were engaged in a...

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Identifiers

PMID: 21576479
DOI: 10.1073/pnas.1016190108
PMCID: PMC3107308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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