Article

Topological basal ganglia model with dopamine-modulated spike-timing-dependent plasticity reproduces reinforcement learning, discriminatory learning, and neuropsychiatric disorders

2025-11-12

Abstract excerpt

<h4>ABSTRACT</h4> The basal ganglia (BG) are central to action selection and reinforcement learning, yet how the topological organization of the BG circuit with dopamine (DA) D1- and D2-receptors shape learning remains unclear. We present a topologically organized spiking model of macaque BG with cortico-striatal inputs organized into competing channels, D1/D2 medium spiny neurons (MSNs), three-factor DA-modulate...

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Literature Corpus work: d836769f-1b33-527c-868a-42eb2f9d92cb
DOI: 10.1101/2025.11.10.687760

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