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Article

Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.

Translational psychiatry - 6 Dec 2021

Chen Hung-Hsin, Petty Lauren E, Sha Jin, Zhao Yi, Kuzma Amanda, Valladares Otto, Bush William, Naj Adam C, Gamazon Eric R, Below Jennifer E

Abstract excerpt

Late-onset Alzheimer disease (LOAD) is highly polygenic, with a heritability estimated between 40 and 80%, yet risk variants identified in genome-wide studies explain only ~8% of phenotypic variance. Due to its increased power and interpretability, genetically regulated expression (GReX) analysis is an emerging approach to investigate the genetic mechanisms of complex diseases. Here, we conducted GReX analysis...

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Identifiers

PMID: 34873149
DOI: 10.1038/s41398-021-01677-0
PMCID: PMC8648734

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