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Article

Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure.

The Journal of pathology - 1 Jun 2020

Rowan Simon C, Jahns Hanne, Mthunzi Liberty, Piouceau Lucie, Cornwell Joanna, Doody Róisín, Frohlich Stephen, Callanan John J, McLoughlin Paul

Abstract excerpt

The intestinal epithelium is perpetually renewed from a stem cell niche in the base of crypts to maintain a healthy bowel mucosa. Exit from this niche and maturation of epithelial cells requires tightly controlled gradients in BMP signalling, progressing from low BMP signalling at the crypt base to high signalling at the luminal surface. The BMP antagonist gremlin 1 (Grem1) is highly expressed by subepithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32297672
DOI: 10.1002/path.5450
PMCID: PMC7384058

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