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Article

The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress.

Biochemical and biophysical research communications - 11 Jun 2020

Masaki So, Hashimoto Kozue, Kihara Daiki, Tsuzuki Chizuru, Kataoka Naoyuki, Suzuki Kenji

Abstract excerpt

Alternative splicing of the pyruvate kinase M (PKM) pre-mRNA generates two isoforms, PKM1 and PKM2. PKM catalyzes the conversion of phosphoenol-pyruvate to pyruvate in glycolytic pathway. PKM1 exist as a stable tetramer that is at an active enzyme state, while PKM2 is in equilibrium among monomer, dimer and tetramer under the regulation of its allosteric activators. Many cancer cells show the feature of higher...

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PMID: 32295714
DOI: 10.1016/j.bbrc.2020.03.182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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