Article
Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Oncogene - 30 Jun 2016
Yang Y-C, Cheng T-Y, Huang S-M, Su C-Y, Yang P-W, Lee J-M, Chen C-K, Hsiao M, Hua K-T, Kuo M-L
Abstract excerpt
Secondary mutation of epidermal growth factor receptor (EGFR) resulting in drug resistance is one of the most critical issues in lung cancer therapy. Several drugs are being developed to overcome EGFR tyrosine kinase inhibitor (TKI) resistance. Here, we report that pyruvate kinase M2 (PKM2) stabilized mutant EGFR protein by direct interaction and sustained cell survival signaling in lung cancer cells. PKM2...
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