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Article

Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.

Biochemistry - 19 Dec 2017

Srivastava Dhiraj, Razzaghi Mortezaali, Henzl Michael T, Dey Mishtu

Abstract excerpt

Pyruvate kinase muscle isoform 2 (PKM2) catalyzes the terminal step in glycolysis, transferring a phosphoryl group from phosphoenolpyruvate to ADP, to produce pyruvate and ATP. PKM2 activity is allosterically regulated by fructose 1,6-bisphosphate (FBP), an upstream glycolytic intermediate. FBP stabilizes the tetrameric form of the enzyme. In its absence, the PKM2 tetramers dissociate, yielding a dimer-monomer...

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Identifiers

PMID: 29182273
DOI: 10.1021/acs.biochem.7b01013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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