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Article

Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.

FEBS letters - 1 Feb 2020

Liu Vivian M, Howell Andrea J, Hosios Aaron M, Li Zhaoqi, Israelsen William J, Vander Heiden Matthew G

Abstract excerpt

Mammalian pyruvate kinase catalyzes the final step of glycolysis, and its M2 isoform (PKM2) is widely expressed in proliferative tissues. Mutations in PKM2 are found in some human cancers; however, the effects of these mutations on enzyme activity and regulation are unknown. Here, we characterized five cancer-associated PKM2 mutations, occurring at various locations on the enzyme, with respect to substrate...

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Identifiers

PMID: 31642061
DOI: 10.1002/1873-3468.13648
PMCID: PMC7042059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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