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Article

Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.

The Journal of biological chemistry - 28 May 2010

Gupta Vibhor, Kalaiarasan Ponnusamy, Faheem Mohammad, Singh Nishant, Iqbal Mohammad Askandar, Bamezai Rameshwar N K

Abstract excerpt

This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cellular milieu resulting in the interaction between the two at the monomer level was substantiated further by in vitro...

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Identifiers

PMID: 20304929
DOI: 10.1074/jbc.M109.065029
PMCID: PMC2878009

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PKM

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.PMID 20304929Read ↗

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