Article
Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2.
Nature communications - 29 Aug 2024
Wang Rong-Hsuan, Chen Pin-Ru, Chen Yue-Ting, Chen Yi-Chang, Chu Yu-Hsin, Chien Chia-Chen, Chien Po-Chen, Lo Shao-Yun, Wang Zhong-Liang, Tsou Min-Chen, Chen Ssu-Yu, Chiu Guang-Shen, Chen Wen-Ling, Wu Yi-Hsuan, Wang Lily Hui-Ching, Wang Wen-Ching, Lin Shu-Yi, Kung Hsing-Jien, Wang Lu-Hai, Cheng Hui-Chun, Lin Kai-Ti
Abstract excerpt
Most cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation. Here we demonstrate that hydrogen sulfide (H2S) destabilizes the PKM2 tetramer into monomer/dimer...
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