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Article

Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients.

BMC cancer - 16 Apr 2020

Tanabe Yuko, Shiraishi Seiji, Hashimoto Kenji, Ikeda Kazutaka, Nishizawa Daisuke, Hasegawa Junko, Shimomura Akihiko, Ozaki Yukinori, Tamura Nobuko, Yunokawa Mayu, Yonemori Kan, Takano Toshimi, Kawabata Hidetaka, Tamura Kenji, Fujiwara Yasuhiro, Shimizu Chikako

Abstract excerpt

BACKGROUND: Sodium channels located in the dorsal root ganglion, particularly Nav1.7 and Nav1.8, encoded by SCN9A and SCN10A, respectively, act as molecular gatekeepers for pain detection. Our aim was to determine the association between TIPN and SCN9A and SCN10A polymorphisms. METHODS: Three single nucleotide polymorphisms (SNPs) in SCN9A and two in SCN10A were investigated using whole-genome genotyping data...

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Identifiers

PMID: 32295642
DOI: 10.1186/s12885-020-06834-0
PMCID: PMC7161266

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