Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p63 regulates glutaminase 2 expression

1 May 2013

Abstract excerpt

The transcription factor p63 is critical for many biological processes, including development and maintenance of epidermal tissues and tumorigenesis. Here, we report that the TAp63 isoforms regulate cell metabolism through the induction of the mitochondrial glutaminase 2 (GLS2) gene both in primary cells and tumor cell lines. By ChIP analysis and luciferase assay, we confirmed that TAp63 binds directly to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23574722
DOI: 10.4161/cc.24478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p63 regulates glutaminase 2 expressionPMID 23574722Read ↗

Epigenetic silencing of glutaminase 2 in human liver and colon cancersSemantic proximity Read ↗

p63 supports aerobic respiration through hexokinase II.Semantic proximity Read ↗

GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular CarcinomaSemantic proximity Read ↗

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinomaSemantic proximity Read ↗

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolismSemantic proximity Read ↗

Glyoxalase II, a Detoxifying Enzyme of Glycolysis Byproduct Methylglyoxal and a Target of p63 and p73, Is a Pro-survival Factor of the p53 FamilySemantic proximity Read ↗

The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 ExpressionSemantic proximity Read ↗

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasisSemantic proximity Read ↗

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiationSemantic proximity Read ↗

TAp63 and DeltaNp63 in cancer and epidermal development.Semantic proximity Read ↗

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.Semantic proximity Read ↗

The Biological and Clinical Significance of Glutaminase in Luminal Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.