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Article

Role of coagulation-associated processes on factor VIII immunogenicity in a mouse model of severe hemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2014

Gangadharan B, Delignat S, Ollivier V, Gupta N, Mackman N, Kaveri S V, Lacroix-Desmazes S

Abstract excerpt

BACKGROUND: Immune responses to therapeutic factor VIII remain a major problem, affecting 30% of patients with severe hemophilia A. The primary factors that drive immune responses in these patients remain elusive. There have been conflicting reports on a role of coagulation (or thrombin) in anti-FVIII immune responses. OBJECTIVE: To assess the importance of coagulation-associated processes for the onset of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25267332
DOI: 10.1111/jth.12740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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