Article

Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII

2022-09-26

Abstract excerpt

Mutations in LMAN1 and MCFD2 cause the combined deficiency of FV and FVIII (F5F8D). LMAN1 and MCFD2 form a protein complex that transport FV and FVIII from the endoplasmic reticulum to the Golgi. Although both proteins are required for the cargo receptor function, little is known about specific roles of LMAN1 and MCFD2 in transporting FV/FVIII. We used different LMAN1 and MCFD2 deficient cell lines to investigat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41219a91-b1f6-5af1-ac0c-dcbe95f965e9
DOI: 10.1101/2022.09.25.509417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIIIDOI 10.1101/2022.09.25.509417Read

Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.Semantic proximity Read

Recent developments in the understanding of the combined deficiency of FV and FVIII.Semantic proximity Read

Combined deficiency of coagulation factors V and VIII: an update.Semantic proximity Read

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII.Semantic proximity Read

Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII).Semantic proximity Read

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.Semantic proximity Read

Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.Semantic proximity Read

Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.Semantic proximity Read

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.Semantic proximity Read

Combined Factor V and Factor VIII Deficiency.Semantic proximity Read

Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.Semantic proximity Read

Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII.Semantic proximity Read