Article
Conformational Characterization of Native and L17A/F19A-Substituted Dutch-Type β-Amyloid Peptides.
International journal of molecular sciences - 7 Apr 2020
He Kai-Cyuan, Chen Yi-Ru, Liang Chu-Ting, Huang Shi-Jie, Tzeng Chung-Ying, Chang Chi-Fon, Huang Shing-Jong, Huang Hsien-Bin, Lin Ta-Hsien
Abstract excerpt
Some mutations which occur in the α/β-discordant region (resides 15 to 23) of β-amyloid peptide (Aβ) lead to familial Alzheimer's disease (FAD). In vitro studies have shown that these genetic mutations could accelerate Aβ aggregation. We recently showed that mutations in this region could alter the structural propensity, resulting in a different aggregative propensity of Aβ. Whether these genetic mutations...
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