Structural analysis of oligomeric and protofibrillar Aβ amyloid pair structures considering F20L mutation effects using molecular dynamics simulations.

Abstract excerpt

Aβ amyloid proteins are involved in neuro-degenerative diseases such as Alzheimer's, Parkinson's, and so forth. Because of its structurally stable feature under physiological conditions, Aβ amyloid protein disrupts the normal cell function. Because of these concerns, understanding the structural feature of Aβ amyloid protein in detail is crucial. There have been some efforts on lowering the structural stabilities...

Topics

• Amino Acid Substitution
• Amyloid beta-Peptides
• Binding Sites
• Humans
• Hydrogen Bonding
• Leucine
• Molecular Dynamics Simulation
• Mutation
• Peptide Fragments
• Phenylalanine
• Protein Binding