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Article

Exploring the complexity of amyloid-beta fibrils: structural polymorphisms and molecular interactions.

Biochemical Society transactions - 28 Aug 2024

Baek Yoongyeong, Lee Myungwoon

Abstract excerpt

The aggregation of amyloid-beta (Aβ) peptides into cross-β structures forms a variety of distinct fibril conformations, potentially correlating with variations in neurodegenerative disease progression. Recent advances in techniques such as X-ray crystallography, solid-state NMR, and cryo-electron microscopy have enabled the development of high-resolution molecular structures of these polymorphic amyloid fibrils,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39034652
DOI: 10.1042/BST20230854

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