Article
Comparative analysis of human and Dutch-type Alzheimer beta-amyloid peptides by infrared spectroscopy and circular dichroism.
Biochemical and biophysical research communications - 26 Feb 1993
Fabian H, Szendrei G I, Mantsch H H, Otvos L
Abstract excerpt
The 42 amino acid beta A4 peptide is the major constituent of the senile plaques, one of the hallmark neuropathological lesions of Alzheimer's disease. While C-terminally truncated variants were shown to be present in normal body fluids, a single Glu-->Gln change in the 39 amino acid form of beta...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloidosis
- Animals
- Brain
- Cerebral Hemorrhage
- Circular Dichroism
- Fourier Analysis
- Genetic Variation
- Humans
- Molecular Sequence Data
- Netherlands
- Peptides
- Protein Conformation
- Rodentia
- Sequence Homology, Amino Acid
- Spectrophotometry, Infrared