Article
Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea Virus.
Viruses - 23 Oct 2015
Chen Fangzhou, Zhu Yinxing, Wu Meizhou, Ku Xugang, Ye Shiyi, Li Zhonghua, Guo Xiaozhen, He Qigai
Abstract excerpt
Since 2010, the variant porcine epidemic diarrhea virus (PEDV) has been the etiological agent responsible for the outbreak of porcine epidemic diarrhea (PED) worldwide. In this study, a variant PEDV strain YN1 was isolated, serially propagated on the Vero cells and was characterized for 200 passages. To better elucidate the molecular basis of Vero cell adaptation of variant PEDV strains, we sequenced, compared,...
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