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Article

Reverse Genetics Approach for Developing Rotavirus Vaccine Candidates Carrying VP4 and VP7 Genes Cloned from Clinical Isolates of Human Rotavirus.

Journal of virology - 22 Dec 2020

Kanai Yuta, Onishi Misa, Kawagishi Takahiro, Pannacha Pimfhun, Nurdin Jeffery A, Nouda Ryotaro, Yamasaki Moeko, Lusiany Tina, Khamrin Pattara, Okitsu Shoko, Hayakawa Satoshi, Ebina Hirotaka, Ushijima Hiroshi, Kobayashi Takeshi

Abstract excerpt

Species A rotaviruses (RVs) are a leading cause of severe acute gastroenteritis in infants and children younger than 5 years. Currently available RV vaccines were adapted from wild-type RV strains by serial passage of cultured cells or by reassortment between human and animal RV strains. These traditional methods require large-scale screening and genotyping to obtain vaccine candidates. Reverse genetics is a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33087468
DOI: 10.1128/JVI.01374-20
PMCID: PMC7944460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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